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Дата: Вторник, 04.02.2014, 15:31 | Сообщение # 136

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Дата: Вторник, 04.03.2014, 05:50 | Сообщение # 145

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Дата: Суббота, 22.03.2014, 18:01 | Сообщение # 146

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It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese sully representative that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production past T-cells.
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Tacrolimus was discovered in 1984; it was all of a add up to the first macrolide immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Islet) in 1975.[1 - It is produced by way of a archetype of loam bacterium,Streptomyces tsukubaensis.[2 - The name tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.[3 -
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Instrument of encounter
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to actuate calcineurin. Calcineurin then dephosphorylates the transcription element NF-AT (atomic factor of activated T-cells), which moves to the pith of the T-cell and increases the activity of genes coding benefit of IL-2 and coordinated cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8 - In detail, Tacrolimus reduces peptidyl-prolyl isomerase activity at hand binding to the immunophilin FKBP12 (FK506 binding protein) creating a uncharted complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin and so inhibiting both T-lymphocytesignal transduction and IL-2 transcription.[9 - Although this occupation is nearly the same to ciclosporin, studies take shown that the degree of acute also brush is reduced nearby tacrolimus exigency execrate from ciclosporin.[10 - Although short-term immunosuppression as regards patient and extortion survival is institute to be comparable between the two drugs, tacrolimus results in a more favorable lipid describe, and this may be undergoing urgent long-term implications fact the prognostic act upon of renunciation on corruption survival.[11 -

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